Contents
Social neuropsychology
Sociological, affective, behavioral, cognitive, and neural mechanisms involved in social interactions.
Leader
Dr. Maxime Bertoux
members
9
Objectives
Our research aims to identify and understand the sociological, affective, behavioural, cognitive, linguistic, and neural mechanisms involved in social interactions. We also investigate how their assessment may help improve early diagnosis, clinical monitoring, and care in neurodegenerative diseases, such as frontotemporal dementia or Alzheimer’s disease, and support their differentiation from psychiatric disorders.
Population
• Neurotypical populations
• Patients with Alzheimer’s disease, behavioural variant frontotemporal dementia (bvFTD), primary progressive aphasia, or atypical psychiatric disorders, all seen at the Lille Memory Resources and Research Centre (CMRR), the French National Reference Centre for Young-Onset Alzheimer’s Disease, and the Constituent Reference Centre for “Rare or Early-Onset Dementias”
Methods
• Approaches from cognitive and experimental psychology
• Clinical neuropsychology and behavioural neurology
• Psycholinguistics and language sciences
• Data-driven statistical analyses and machine learning methods
• Structural and functional neuroimaging
• Participatory research and interviews
• Digital markers
Team members
Leader
Team
- TT
Pr. Thi Mai Tran
Professor in Rehabilitation Sciences
- MM
Dr. Marie-Anne Mackowiak
Hospital Practitioner in Neurology, Head of Day Hospital at CMRR
- AR
Dr. Adeline Rollin
Hospital Practitioner in Neurology, Head of CNRMAJ at CMRR
- FE
Dr. Florent El Grabli
Hospital Practitioner in Neurology & Pain Medicine
Dr. Agnès Denève
Postdoctoral Researcher & Neuropsychologist
Aurore Dubos
PhD Student & Speech Therapist
- FP
Dr. Florence Plumacker
Neurology Trainee
- WC
Wiam Cherif
PhD Student & Neuropsychologist
Publications
PatientSpace: A multimodal graph-based latent representation framework for modeling neurodegenerative disease heterogeneity.
Manouvriez D, Kuchcinski G, Lecerf S, Lahousse H, Rogeau A, Villain N, Kas A, Pyatigorskaya N, Nguyen M, Petrovic S, Cole JH, Zabihi M, Hache B, Bertoux M, Lebouvier T, Roca V, Lopes R, Alzheimer’s Disease Neuroimaging Initiative, Frontotemporal Lobar Degeneration Neuroimaging Initiative, MEMENTO study group, SOCRATES study group · NeuroImage
Trajectories of brain structure and function in young adult carriers of genetic frontotemporal dementia variants.
So I, Lombardi J, Staffaroni AM, Coleman KKL, Bouzigues A, Ferry-Bolder E, Cullen E, Russell LL, Foster PH, Farley S, Convery R, van Swieten JC, Jiskoot LC, Seelaar H, Galimberti D, Vandenberghe R, Laforce R, Bruffaerts R, Bertoux M, Lebouvier T, Solje E, Levin J, di Fede G, Thompson A, Le Ber I, Migliaccio RL, Körtvélyessy P, Schroeter ML, Logroscino G, Otto M, Uzelac Z, Illán-Gala I, Krüger J, Nacmias B, Gerhard A, Langheinrich T, Ducharme S, Santana I, Tartaglia MC, Masellis M, de Mendonça A, Rowe JB, Graff C, Moreno F, Synofzik M, Borroni B, Sanchez-Valle R, Brushaber D, Considine CM, Faber K, Fagan A, Fields JA, Foroud T, Forsberg LK, Gendron T, Geschwind D, Heuer HW, Huang E, Kantarci K, Kolander T, Lago AL, Lavigne SB, Mester C, Molden J, Petrucelli L, Rademakers R, Ramos EM, Rankin KP, Rascovsky K, Rhoads KW, Vandeberghe M, Weintraub S, Wong B, Boeve BF, Boxer AL, Rosen HJ, Lee SE, Rohrer JD, Finger EC · medRxiv : the preprint server for health sciences
Composite grey matter fingerprints for genetic frontotemporal dementia.
Bouzigues A, Campana G, Joulot M, Gensollen N, Russell LL, Foster PH, Ferry-Bolder E, Van Swieten JC, Jiskoot LC, Seelaar H, Sánchez-Valle R, Laforce R, Graff C, Galimberti D, Vandenberghe R, de Mendonca A, Tiraboschi P, Santana I, Gerhard A, Levin J, Sorbi S, Otto M, Bertoux M, Lebouvier T, Ducharme S, Butler C, Finger E, Tartaglia MC, Masellis M, Rowe JB, Synofzik M, Moreno F, Borroni B, Leber I, Zanusso G, Rohrer JD, Migliaccio R, GENetic Frontotemporal dementia Initiative (GENFI) · Journal of neurology, neurosurgery, and psychiatry
Expressive prosody in behavioral variant frontotemporal degeneration and late-onset psychiatric disorders.
Denève A, Villain M, Bordier C, Denis C, Carpentier C, Forestier N, Renard A, Dumont J, Lopes R, Kuchcinski G, D'Hondt F, Amad A, Lebouvier T, Bertoux M · Neuropsychology
AI-powered analysis of affective dimensions in speech and its relevance for FTD diagnosis.
Denève A, Dauchez R, Lebouvier T, D'Hondt F, Bertoux M · Alzheimer's & dementia (Amsterdam, Netherlands)
Multi-level language deficits in behavioural frontotemporal degeneration and related disorders.
Denève A, Mahut Dubos A, Tran TM, Renard A, Carpentier C, Forestier N, Kuchcinski G, Lopes R, Amad A, Lebouvier T, Bertoux M · Brain communications
Survival estimates and their predictors in genetic frontotemporal dementia: an international, retrospective, cohort study.
Bouzigues A, Grassi M, Cantoni V, Premi E, Bellini S, Binetti G, Logroscino G, Russell LL, Ferry-Bolder E, Foster PH, van Swieten JC, Jiskoot LC, Seelaar H, Sanchez-Valle R, Laforce R, Graff C, Galimberti D, Vandenberghe R, de Mendonça A, Di Fede G, Santana I, Gerhard A, Langheinrich T, Levin J, Nacmias B, Otto M, Bertoux M, Lebouvier T, Ducharme S, Butler C, le Ber I, Bruffaerts R, Solje E, Kinnunen M, Krüger J, Finger E, Tartaglia MC, Masellis M, Rowe JB, Synofzik M, Moreno F, Ghidoni R, Migliaccio R, Rohrer JD, Borroni B, GENFI consortium · The Lancet. Neurology
Related projects
Digital markers of social cognition for diagnosis and prognosis in neurodegenerative diseases
DISCeRN develops digital markers of social cognition to improve differential diagnosis and prognosis in neurodegenerative diseases, combining AI, clinical neuropsychology and brain imaging.
Social Cognition: From Brain to Society
SOCIALIZE develops and validates new neuropsychological tests to assess social cognition — social norms, social memory, trust, emotional semantics — in patients with FTD and Alzheimer's disease.